Journal article
Flobater Gawargi, P. Mishra
American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2023
American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2023
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APA
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Gawargi, F., & Mishra, P. (2023). Ironing Out the Details: Ferroptosis and its Relevance to Diabetic Cardiomyopathy. American Journal of Physiology. Regulatory Integrative and Comparative Physiology.
Chicago/Turabian
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Gawargi, Flobater, and P. Mishra. “Ironing Out the Details: Ferroptosis and Its Relevance to Diabetic Cardiomyopathy.” American Journal of Physiology. Regulatory Integrative and Comparative Physiology (2023).
MLA
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Gawargi, Flobater, and P. Mishra. “Ironing Out the Details: Ferroptosis and Its Relevance to Diabetic Cardiomyopathy.” American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2023.
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@article{flobater2023a,
title = {Ironing Out the Details: Ferroptosis and its Relevance to Diabetic Cardiomyopathy.},
year = {2023},
journal = {American Journal of Physiology. Regulatory Integrative and Comparative Physiology},
author = {Gawargi, Flobater and Mishra, P.}
}
Abstract
Ferroptosis is a newly identified myocardial cell death mechanism driven by iron-dependent lipid peroxidation. The presence of elevated intramyocardial lipid levels and excessive iron in diabetic patients suggest a predominant role of ferroptosis in diabetic cardiomyopathy. Since myocardial cell death is a precursor of heart failure and intensive glycemic control cannot abate the increased risk of heart failure in diabetic patients, targeting myocardial cell death via ferroptosis is a promising therapeutic avenue to prevent and/or treat diabetic cardiomyopathy. This review presents updated and comprehensive knowledge on mechanisms underpinning ferroptosis, clarifies several misconceptions about ferroptosis, emphasizes the importance of ferroptosis in diabetes-induced myocardial cell death, and offers valuable approaches to evaluate and target ferroptosis in the diabetic heart. Furthermore, basic concepts and ideas rendered in this review, including glutathione peroxidase-4-independent and mitochondrial mechanisms of ferroptosis, are also critical for investigating ferroptosis in other diabetic organs, as well as non-diabetic and metabolically compromised hearts.