Journal article
Tyler N. Kambis, S. Kar, P. Mishra
The FASEB Journal, 2022
The FASEB Journal, 2022
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APA
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Kambis, T. N., Kar, S., & Mishra, P. (2022). miR‐133a Mitigates Ferroptosis by Attenuating Fatty Acid Metabolism in the Diabetic Heart. The FASEB Journal.
Chicago/Turabian
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Kambis, Tyler N., S. Kar, and P. Mishra. “MiR‐133a Mitigates Ferroptosis by Attenuating Fatty Acid Metabolism in the Diabetic Heart.” The FASEB Journal (2022).
MLA
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Kambis, Tyler N., et al. “MiR‐133a Mitigates Ferroptosis by Attenuating Fatty Acid Metabolism in the Diabetic Heart.” The FASEB Journal, 2022.
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@article{tyler2022a,
title = {miR‐133a Mitigates Ferroptosis by Attenuating Fatty Acid Metabolism in the Diabetic Heart},
year = {2022},
journal = {The FASEB Journal},
author = {Kambis, Tyler N. and Kar, S. and Mishra, P.}
}
Abstract
Myocardial lipid accumulation occurs prior to the development of cardiac dysfunction in patients with diabetes mellitus (DM). miR‐133a prevents DM‐induced myocardial lipid deposition and is decreased in the DM heart, however its cardioprotective mechanisms remain unknown. Ferroptotic cell death which results from an increase in lipid peroxidation combined with a failure of lipid‐antioxidant mechanisms in the presence of iron, is upregulated in the DM heart. Thus, we hypothesize that overexpression of miR‐133a protects against ferroptotic cell death via inhibition of lipid accumulation, leading to decreased lipid peroxidation in the DM heart. We developed a novel Akita/miR‐133aTg (Ak/Tg) mouse model by crossbreeding DM Akita (Ak) with cardiac specific miR‐133a Tg (Tg) to elucidate how miR‐133a regulates ferroptotic cell death in the DM heart.