Journal article
Mediha Becirovic-Agic, Upendra Chalise, M. Daseke, Shelby R. Konfrst, J. Salomon, P. Mishra, M. Lindsey
Biomolecules, 2021
Biomolecules, 2021
Semantic Scholar
DOI
PubMedCentral
PubMed
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APA
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Becirovic-Agic, M., Chalise, U., Daseke, M., Konfrst, S. R., Salomon, J., Mishra, P., & Lindsey, M. (2021). Infarct in the Heart: What’s MMP-9 Got to Do with It? Biomolecules.
Chicago/Turabian
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Becirovic-Agic, Mediha, Upendra Chalise, M. Daseke, Shelby R. Konfrst, J. Salomon, P. Mishra, and M. Lindsey. “Infarct in the Heart: What’s MMP-9 Got to Do with It?” Biomolecules (2021).
MLA
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Becirovic-Agic, Mediha, et al. “Infarct in the Heart: What’s MMP-9 Got to Do with It?” Biomolecules, 2021.
BibTeX Click to copy
@article{mediha2021a,
title = {Infarct in the Heart: What’s MMP-9 Got to Do with It?},
year = {2021},
journal = {Biomolecules},
author = {Becirovic-Agic, Mediha and Chalise, Upendra and Daseke, M. and Konfrst, Shelby R. and Salomon, J. and Mishra, P. and Lindsey, M.}
}
Abstract
Over the past three decades, numerous studies have shown a strong connection between matrix metalloproteinase 9 (MMP-9) levels and myocardial infarction (MI) mortality and left ventricle remodeling and dysfunction. Despite this fact, clinical trials using MMP-9 inhibitors have been disappointing. This review focuses on the roles of MMP-9 in MI wound healing. Infiltrating leukocytes, cardiomyocytes, fibroblasts, and endothelial cells secrete MMP-9 during all phases of cardiac repair. MMP-9 both exacerbates the inflammatory response and aids in inflammation resolution by stimulating the pro-inflammatory to reparative cell transition. In addition, MMP-9 has a dual effect on neovascularization and prevents an overly stiff scar. Here, we review the complex role of MMP-9 in cardiac wound healing, and highlight the importance of targeting MMP-9 only for its detrimental actions. Therefore, delineating signaling pathways downstream of MMP-9 is critical.