Paras Kumar Mishra, PhD

Associate Professor at University of Nebraska Medical Center


Curriculum vitae



Cellular and Integrative Physiology

University of Nebraska Medical Center



Guidelines for evaluating myocardial cell death.


Journal article


P. Mishra, A. Adameová, Joseph A. Hill, C. Baines, P. Kang, J. Downey, J. Narula, Masafumi Takahashi, A. Abbate, H. Piristine, S. Kar, Shi Su, Jason K Higa, Nicholas K. Kawasaki, T. Matsui
American Journal of Physiology. Heart and Circulatory Physiology, 2019

Semantic Scholar DOI PubMed
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APA   Click to copy
Mishra, P., Adameová, A., Hill, J. A., Baines, C., Kang, P., Downey, J., … Matsui, T. (2019). Guidelines for evaluating myocardial cell death. American Journal of Physiology. Heart and Circulatory Physiology.


Chicago/Turabian   Click to copy
Mishra, P., A. Adameová, Joseph A. Hill, C. Baines, P. Kang, J. Downey, J. Narula, et al. “Guidelines for Evaluating Myocardial Cell Death.” American Journal of Physiology. Heart and Circulatory Physiology (2019).


MLA   Click to copy
Mishra, P., et al. “Guidelines for Evaluating Myocardial Cell Death.” American Journal of Physiology. Heart and Circulatory Physiology, 2019.


BibTeX   Click to copy

@article{p2019a,
  title = {Guidelines for evaluating myocardial cell death.},
  year = {2019},
  journal = {American Journal of Physiology. Heart and Circulatory Physiology},
  author = {Mishra, P. and Adameová, A. and Hill, Joseph A. and Baines, C. and Kang, P. and Downey, J. and Narula, J. and Takahashi, Masafumi and Abbate, A. and Piristine, H. and Kar, S. and Su, Shi and Higa, Jason K and Kawasaki, Nicholas K. and Matsui, T.}
}

Abstract

Cell death is a fundamental process in cardiac pathologies. Recent studies revealed multiple forms of cell death, and several of them have been demonstrated to underlie adverse cardiac remodeling and heart failure. With the expansion in the area of myocardial cell death and increasing concerns over rigor and reproducibility, it is important and timely to set a guideline for the best practices of evaluating myocardial cell death. There are six major forms of regulated cell death observed in cardiac pathologies namely apoptosis, necroptosis, mitochondrial-mediated necrosis, pyroptosis, ferroptosis, and autophagic cell death. In this article, we described the best methods to identify, measure, and evaluate these modes of myocardial cell death. In addition, we discussed the limitations of currently practiced myocardial cell death mechanisms.


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