Journal article
Natia Qipshidze, P. Mishra, Naira S. Metreveli, D. Lominadze, Suresh Tyagi
2011
2011
Semantic Scholar
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APA
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Qipshidze, N., Mishra, P., Metreveli, N. S., Lominadze, D., & Tyagi, S. (2011). Hydrogen sulfide improves angiogenesis and regulates cardiac function and structure during myocardial infarction in mice.
Chicago/Turabian
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Qipshidze, Natia, P. Mishra, Naira S. Metreveli, D. Lominadze, and Suresh Tyagi. “Hydrogen Sulfide Improves Angiogenesis and Regulates Cardiac Function and Structure during Myocardial Infarction in Mice” (2011).
MLA
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Qipshidze, Natia, et al. Hydrogen Sulfide Improves Angiogenesis and Regulates Cardiac Function and Structure during Myocardial Infarction in Mice. 2011.
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@article{natia2011a,
title = {Hydrogen sulfide improves angiogenesis and regulates cardiac function and structure during myocardial infarction in mice},
year = {2011},
author = {Qipshidze, Natia and Mishra, P. and Metreveli, Naira S. and Lominadze, D. and Tyagi, Suresh}
}
Abstract
Previously we showed that the homocysteine (Hcy) level was increased during the myocardial infarction (MI), which was caused by decreasing of Hcy lowering factors, cystathionine β‐synthase and cystathionine γ‐lyase (CGL). It is known that hydrogen sulfide (H2S) is a cardioprotective agent and decreases the level of Hcy in the heart. In the present study we tested its cardio protective potential during MI. MI was induced in 12‐week‐old mice by ligation of left anterior descending artery. Sham surgery was performed except the ligation. After the surgery, mice were given drinking water with or without sodium hydrosulfide (NaHS, H2S donor) for 4 weeks. Levels of VEGF, flk‐1 and flt‐1 were significantly increased and the expression of anti‐angiogenic proteins (endostatin, angiostatin, parstatin) were decreased in treated mice compared to the untreated, control group. The echocardiography showed improvement in heart function in treated mice compared to control group. This observed cytoprotection was associated with a downregulation of anti‐angiogenic proteins and stimulation of angiogenesis. In addition, we found that treatment with NaHS significantly increasef the level of CGL, which significantly lowered the damaged part. The present study demonstrates that H2S, through cytoprotection and angioprotection, ameliorates infarct size and preserves left ventricular function during MI.
