Paras Kumar Mishra, PhD

Associate Professor at University of Nebraska Medical Center


Curriculum vitae



Cellular and Integrative Physiology

University of Nebraska Medical Center



MMP9: Targeting a Key Enzyme in Diabetic Heart Disease


Our lab is at the forefront of investigating matrix metalloproteinase-9 (MMP9) and its role in diabetic cardiomyopathy. MMP9, an enzyme known for its involvement in tissue remodeling, is believed to play a critical role in the structural and functional alterations observed in diabetic hearts.

In diabetic patients, MMP9 levels are often dysregulated, leading to excessive breakdown of extracellular matrix components in the heart. This process contributes to the fibrosis, inflammation, and eventual weakening of cardiac tissue, heightening the risk of heart failure. Our project aims to elucidate the specific mechanisms by which MMP9 contributes to heart disease in diabetes and to develop targeted interventions.

Through cutting-edge molecular techniques and advanced cardiac imaging, we are exploring the effects of MMP9 inhibition in diabetic heart models. Our preliminary data suggests that controlling MMP9 activity could significantly mitigate the progression of heart disease in diabetics, offering a promising new avenue for treatment.

This project not only enhances our understanding of diabetic cardiomyopathy but also paves the way for novel therapeutic strategies to combat this increasingly common and devastating condition. With a strong focus on translational research, we are committed to translating our findings into clinical applications that can improve the lives of millions suffering from diabetic heart disease.

Ablation of MMP9 mitigates cell death in human cardiac stem cells
A novel interaction between MMP9 and SOD3

Publications


Deciphering MMP9's Dual Role in Regulating SOD3 through Protein-Protein Interaction.


Flobater Gawargi, Paras K Mishra

Canadian Journal of Physiology and Pharmacology, 2023


Cardiomyocyte‐Specific Transgenic MMP9 Overexpression Induces Cardiac Remodeling


Hamid R. Shahshahan, Bryan T. Hackfort, P. Mishra

The FASEB Journal, 2021


Infarct in the Heart: What’s MMP-9 Got to Do with It?


Mediha Becirovic-Agic, Upendra Chalise, M. Daseke, Shelby R. Konfrst, J. Salomon, P. Mishra, M. Lindsey

Biomolecules, 2021


MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro


S. Yadav, Tyler N. Kambis, S. Kar, S. Park, P. Mishra

Cell Death and Disease, 2020


Ablation of MMP9 upregulates autophagic flux in the diabetic heart


S. Nandi, P. Mishra

The FASEB Journal, 2017


Role Of MMP9 In Cardiac Stem Cell Differentiation And Autophagy


P. Mishra, Naira S. Metreveli, Vishalakshi Chavali, N. Tyagi, Natia Qipshidze, U. Sen, I. Joshua, S. Tyagi

2012


Ablation of MMP9 induces survival and differentiation of cardiac stem cells into cardiomyocytes in the heart of diabetics: a role of extracellular matrix.


P. Mishra, Vishalakshi Chavali, Naira S. Metreveli, S. Tyagi

Canadian Journal of Physiology and Pharmacology, 2012


MMP-9 Gene Ablation and TIMP-4 Mitigate PAR-1-Mediated Cardiomyocyte Dysfunction: A Plausible Role of Dicer and miRNA


P. Mishra, Naira S. Metreveli, S. Tyagi

Cell Biochemistry and Biophysics, 2010


MMP-2/TIMP-2/TIMP-4 versus MMP-9/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failure*


S. Givvimani, N. Tyagi, U. Sen, P. Mishra, Natia Qipshidze, C. Munjal, Jonathan C. Vacek, O. Abe, S. Tyagi

Archives of Physiology and Biochemistry, 2010


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