Paras Kumar Mishra, PhD

Associate Professor at University of Nebraska Medical Center


Curriculum vitae



Cellular and Integrative Physiology

University of Nebraska Medical Center



MicroRNA-133a: A Novel Cardioprotective Agent in Diabetic Cardiomyopathy


In our ongoing battle against diabetic cardiomyopathy, a severe diabetes complication, our lab is at the forefront of research on microRNA-133a, a promising agent for heart protection. This project merges molecular biology with cardiac healthcare, focusing on the therapeutic use of microRNA-133a for diabetic patients.
Diabetic cardiomyopathy causes serious changes in heart structure and function, increasing the risk of heart failure. MicroRNA-133a, a small, non-coding RNA, plays a vital role in regulating heart muscle cells. In diabetic conditions, its levels drop, exacerbating heart damage. Our innovative approach involves administering microRNA-133a to rebalance its levels in the diabetic heart. Early results in preclinical models are encouraging: elevated microRNA-133a levels correlate with better cardiac function, less fibrosis, and improved cell survival.
This research isn't just about managing symptoms; it's a game-changer in treating diabetic cardiomyopathy's molecular causes. MicroRNA-133a targets specific pathways in heart muscle decay, potentially reshaping treatment methods for diabetic heart disease.
We're pioneering in understanding how microRNAs, especially microRNA-133a, can be powerful tools against diabetic heart disease. This project, fueled by extensive research and collaboration, offers new hope for millions grappling with diabetes' cardiac complications.

Publications


miR‐133a Mitigates Ferroptosis by Attenuating Fatty Acid Metabolism in the Diabetic Heart


Tyler N. Kambis, S. Kar, P. Mishra

The FASEB Journal, 2022


Regulating Polyamine Metabolism by miRNAs in Diabetic Cardiomyopathy


Tyler N. Kambis, Hadassha M. N. Tofilau, Flobater Gawargi, S. Chandra, P. Mishra

Current Diabetes Reports, 2021


MiR-133a Mimic Alleviates T1DM-Induced Systolic Dysfunction in Akita: An MRI-Based Study


S. Nandi, Hamid R. Shahshahan, Q. Shang, S. Kutty, M. Boska, P. Mishra

Frontiers in Physiology, 2018


Targeting miRNA for Therapy of Juvenile and Adult Diabetic Cardiomyopathy.


S. Nandi, P. Mishra

Advances in Experimental Medicine and Biology, 2018


A novel role for miR-133a in centrally mediated activation of the renin-angiotensin system in congestive heart failure.


Neeru M. Sharma, S. Nandi, Hong Zheng, P. Mishra, K. Patel

American Journal of Physiology. Heart and Circulatory Physiology, 2017


Induction of autophagy markers is associated with attenuation of miR-133a in diabetic heart failure patients undergoing mechanical unloading.


S. Nandi, M. Duryee, Hamid R. Shahshahan, G. Thiele, D. Anderson, P. Mishra

American journal of translational research, 2015


MicroRNomics of Diabetic Cardiomyopathy


P. Mishra, S. Tyagi

2014


miR‐133a ameliorates cardiac dysfunction in diabetes: possibly by restoring β‐adrenergic receptor function and expression (1078.6)


S. Nandi, Xuefei Liu, Hong Zheng, Neeru M. Sharma, Vishalakshi Chavali, K. Patel, P. Mishra

2014


P59 H2S ameliorates homocysteine mediated attenuation of miR-133a and β2-AR in diabetic hearts


P. Mishra, Vishalakshi Chavali, Pushpakumar Sathur, Natia Qipshidze, S. Tyagi

2012


MiR‐133 As An Epigenetic Regulator Of Diabetic Heart Failure


Vishalakshi Chavali, N. Tyagi, S. Tyagi, P. Mishra

2012


MicroRNA-133a regulates DNA methylation in diabetic cardiomyocytes.


Vishalakshi Chavali, S. Tyagi, P. Mishra

Biochemical and Biophysical Research Communications - BBRC, 2012


Role of MicroRNAs in homocysteine induced oxidative stress


P. Mishra, N. Tyagi, Munish Kumar, Soumi Kundu, S. Givvimani, U. Sen, S. Tyagi

2009


MicroRNAs as a therapeutic target for cardiovascular diseases


P. Mishra, N. Tyagi, Munish Kumar, S. Tyagi

Journal of Cellular and Molecular Medicine, 2009


MicroRNAs Are Involved in Homocysteine-Induced Cardiac Remodeling


P. Mishra, N. Tyagi, Soumi Kundu, S. Tyagi

Cell Biochemistry and Biophysics, 2009


Share



Follow this website


You need to create an Owlstown account to follow this website.


Sign up

Already an Owlstown member?

Log in